Endocrine Abstracts

Background: Cardiovascular events are the major cause of mortality among patients with type 2 diabetes mellitus (DM2). Menopause in women additionally increases cardiovascular risk. Despite myocardial infarction (MI) treatment approach in diabetic patients is not specific, some glucose-lowering drugs could have cardioprotective properties. In general, most glucagon-like peptide-1 receptor agonists (GLP-1Ra) and sodium-glucose co-transporter-2 inhibitors (SGLT-2i) have cardiova...

Background: Presently, a great deal of attention is being paid to investigation of pleiotropic effects of oral antidiabetic drugs. Several recent animal studies have suggested that vildagliptin and metformin could play some positive role in preventing the evolvement of diabetic nephropathy.Aim: This pilot study, concerned with high-fat fed heminephrectomized streptozotocin (STZ)-induced diabetic rats, aimed to evaluate and compare the effects of metformi...